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Bacterial-Mediated Knockdown of Tumor Resistance to an Oncolytic Virus Enhances Therapy

Authors: Cronin M., LeBoeu F., Murphy C., Roy DG, Bell JC, Tangney M

Date: February 26, 2014

Published: Molecular Therapy

Full Article: http://www.nature.com/mt/journal/vaop/ncurrent/full/mt201423a.html

Oncolytic viruses (OVs) and bacteria share the property of tumor-selective replication following systemic administration. In the case of nonpathogenic bacteria, tumor selectivity relates to their ability to grow extracellularly within tumor stroma and is therefore ideally suited to restricting the production of bacterially produced therapeutic agents to tumors.

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