Authors: Cronin M., LeBoeu F., Murphy C., Roy DG, Bell JC, Tangney M
Date: February 26, 2014
Published: Molecular Therapy
Oncolytic viruses (OVs) and bacteria share the property of tumor-selective replication following systemic administration. In the case of nonpathogenic bacteria, tumor selectivity relates to their ability to grow extracellularly within tumor stroma and is therefore ideally suited to restricting the production of bacterially produced therapeutic agents to tumors.